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Ese ikizamini cyoroshye cy’inkari gishobora kugaragaza indwara ya Alzheimer ikiri mu cyiciro cya mbere, bigategura inzira yo gupima abantu benshi? Inyigo nshya ya Frontiers in Aging Neuroscience irabyerekana rwose. Abashakashatsi bapimye itsinda rinini ry’abarwayi ba Alzheimer bafite ubukana butandukanye kandi bafite ubuzima bwiza kandi bari basanzwe mu bwenge kugira ngo bamenye itandukaniro riri mu bipimo by’inkari.
Basanze aside formike mu nkari ari ikimenyetso cy’uko umuntu yagabanutse mu buryo bw’imitekerereze kandi gishobora kuba ikimenyetso cy’intambwe za mbere z’indwara ya Alzheimer. Uburyo buriho bwo gusuzuma indwara ya Alzheimer burahenze, ntiburoroshye, kandi ntibushobora gupimwa buri gihe. Ibi bivuze ko abarwayi benshi bapimwa gusa iyo igihe kigeze ngo bahabwe ubuvuzi bwiza. Ariko, isuzuma ry’inkari ritavangiye, rihendutse kandi ryoroshye rishobora kuba ari ryo abaganga basaba kugira ngo bapimwe hakiri kare.
Abanditsi bagira bati: “Indwara ya Alzheimer ni indwara idakira kandi idakira, bivuze ko ishobora gukura no gukomeza imyaka myinshi mbere yuko ubumuga bwo mu mutwe bugaragara.” Intambwe za mbere z’iyi ndwara ziba mbere y’icyiciro cya dementia idakira, ari na yo nzira nziza yo kuvura no kuvura. Kubwibyo, ni ngombwa gusuzuma indwara ya Alzheimer mu gihe cy’intangiriro z’igihe gito mu bageze mu za bukuru.”
Niba rero ari ingenzi, kuki tudafite gahunda zo gusuzuma indwara ya Alzheimer ikiri mu cyiciro cya mbere? Ikibazo kiri mu buryo abaganga bakoresha ubu. Muri ubwo buryo harimo positron emission tomography y'ubwonko, ihenze kandi igatuma abarwayi bahura n'imirasire y'imirasire. Hariho kandi ibizamini bya biomarker bishobora kugaragaza Alzheimer, ariko bisaba gukururwa amaraso cyangwa gupfunyikwa mu ruhu kugira ngo haboneke amazi yo mu bwonko, abarwayi bashobora kuba babyirengagiza.
Ariko, ibizamini by'inkari ntabwo ari ibintu bibangamira abantu benshi kandi byoroshye, bigatuma biba byiza mu gusuzuma indwara ya Alzheimer. Nubwo abashakashatsi babanje kugaragaza ibimenyetso by'indwara ya Alzheimer mu nkari, nta na kimwe gikwiriye mu kumenya indwara ikiri mu ntangiriro, bivuze ko inzira nziza yo kuvura hakiri kare itaraboneka.
Abashakashatsi bakoze ubushakashatsi bushya bigeze kwiga ku kintu cy’umwimerere cyitwa formaldehyde nk’ikimenyetso cy’inkari ku ndwara ya Alzheimer. Ariko, hari umwanya wo kunoza uburyo indwara ziboneka hakiri kare. Muri ubu bushakashatsi buheruka, bibanze kuri formate, metabolite ya formaldehyde, kugira ngo barebe niba ikora neza nk’ikimenyetso cy’inkari.
Abantu 574 bitabiriye ubu bushakashatsi, kandi abitabiriye bari abakorerabushake bazima mu buryo busanzwe cyangwa bari bafite urwego rutandukanye rw'indwara, kuva ku kugabanuka k'ubwenge kugeza ku kurwara burundu. Abashakashatsi basesenguye ingero z'inkari n'amaraso by'abitabiriye ubu bushakashatsi banakora isuzuma ry'imitekerereze.
Ubushakashatsi bwagaragaje ko urugero rwa aside formike y’inkari rwari rwiyongereye cyane mu matsinda yose y’indwara ya Alzheimer kandi rufitanye isano no kugabanuka k’ubushobozi bwo gutekereza ugereranije n’abantu bafite ubuzima bwiza, harimo n’itsinda ry’abantu bafite ubwonko bwatangiye kugabanuka. Ibi bigaragaza ko aside formike ishobora kuba ikimenyetso cy’ingenzi cy’indwara ya Alzheimer.
Igishimishije ni uko ubwo abashakashatsi basesenguraga urugero rw’inkari mu maraso hamwe n’ibipimo by’amaraso ya Alzheimer, basanze bashobora kumenya neza icyiciro cy’indwara umurwayi arimo. Ariko, hakenewe ubushakashatsi bw’inyongera kugira ngo hubahirizwe isano iri hagati y’indwara ya Alzheimer na aside formike.
Abanditsi bagira bati: “Aside formike y’inkari yagaragaje ubushobozi bwo gupima indwara ya Alzheimer hakiri kare. Gupima indwara ya Alzheimer hifashishijwe ikoranabuhanga ryo mu nkari biroroshye kandi bihendutse kandi bigomba gushyirwa mu isuzuma risanzwe ry’ubuzima bw’abageze mu zabukuru.”
Wang, Y. et al. (2022) Isuzuma rya sisitemu rya aside formike y'inkari nk'ikimenyetso gishya gishobora kugaragara ku ndwara ya Alzheimer. Imbibi mu mikorere y'ubwonko mu gusaza. doi.org/10.3389/fnagi.2022.1046066.
Amatagisi: gusaza, indwara ya Alzheimer, ibimenyetso by'indwara, amaraso, ubwonko, indwara zidakira, indwara zidakira, ibinyabutabire, indwara zo mu mutwe, gusuzuma indwara, abaganga, formaldehyde, ubwonko, positron emission tomography, ubushakashatsi, tomography, isesengura ry'inkari
Muri Pittcon 2023 i Philadelphia, muri Pennsylvania, twaganiriye na Porofeseri Joseph Wang, watsindiye igihembo cya Ralph N. Adams cy’uyu mwaka mu bijyanye n’ubutabire mu by’isesengura, ku bijyanye n’uburyo ikoranabuhanga ry’ibinyabutabire rikoresha ikoranabuhanga rikora ku buryo butandukanye.
Muri iki kiganiro, turaganira ku isuzuma ry’ubuhumekero n’uburyo rishobora kuba igikoresho cy’ingirakamaro cyo kwiga ibimenyetso by’indwara kugira ngo hamenyekane indwara hakiri kare hamwe na Mariana Leal, Umuyobozi w’Itsinda rya Owlstone Medical.
Nk'igice cy'isuzuma ryacu rya SLAS US 2023, turaganira kuri laboratwari y'ejo hazaza n'uko ishobora kumera hamwe na Luigi Da Via, Umuyobozi w'Itsinda Rishinzwe Guteza Imbere Ibipimo bya GSK.
News-Medical.Net itanga iyi serivisi y'amakuru yerekeye ubuvuzi hakurikijwe aya mategeko n'amabwiriza. Nyamuneka menya ko amakuru y'ubuvuzi ari kuri uru rubuga agamije gushyigikira, ntabwo ari ugusimbura, umubano w'umuganga/umurwayi ndetse n'inama z'ubuvuzi bashobora gutanga.