Iyi nkuru yasuzumwe hakurikijwe amabwiriza n'amabwiriza ya Science X yo kwandika. Abanditsi bashimangiye ibintu bikurikira mu gihe bagenzura ko ibikubiye muri iyi nkuru ari ukuri:
Urusobe rw'inyuma rw'ibihumyo na bagiteri, rwitwa "extracellular matrix" cyangwa ECM, rufite imiterere nk'iya jeli kandi rukora nk'urusobe rw'uburinzi n'igishishwa. Ariko nk'uko ubushakashatsi buherutse gusohoka mu kinyamakuru iScience, cyakozwe na Kaminuza ya Massachusetts Amherst ku bufatanye na Worcester Polytechnic Institute bubigaragaza, ECM ya mikorobe zimwe na zimwe ikora jeli gusa iyo hari aside oxalic cyangwa izindi aside zoroshye. googletag.cmd.push(function() { googletag.display('div-gpt-ad-1449240174198-2′); });
Kubera ko ECM igira uruhare runini muri byose kuva ku kudakira kwa antibiyotike kugeza ku miyoboro yazibye no kwanduza ibikoresho by’ubuvuzi, gusobanukirwa uburyo mikorobe zikoresha urwego rwazo rwa gel zifata bigira ingaruka nini ku buzima bwacu bwa buri munsi.
Barry Goodell, umwarimu wa mikorobe muri Kaminuza ya Massachusetts Amherst akaba n'umwanditsi mukuru w'iyi nyandiko yagize ati: “Nahoraga nshishikajwe na mikorobe za ECM.” “Abantu bakunze gutekereza kuri ECM nk'urwego rw'inyuma rudakora rurinda mikorobe. Ariko ishobora no gukora nk'umuyoboro wemerera intungamubiri na enzymes kwinjira no gusohoka mu turemangingo twa mikorobe.”
Iyi mikorobe ifite inshingano nyinshi: kuba ifatana bivuze ko udukoko twinshi dushobora kwishyira hamwe tugakora koloni cyangwa "biofilms", kandi iyo udukoko twinshi tubikoze, dushobora kuziba imiyoboro cyangwa kwanduza ibikoresho by'ubuvuzi.
Ariko igishishwa kigomba kandi kuba cyoroshye kwinjiramo. Udukoko twinshi dusohora imisemburo itandukanye n'ibindi bintu bya metabolite binyuze muri ECM mu bintu dushaka kurya cyangwa kwanduza (nk'ibiti bibora cyangwa inyama z'inyamaswa zo mu mugongo), hanyuma, iyo imisemburo irangije akazi kayo ko gusya, yimura intungamubiri binyuze muri ECM. Icyo kintu gisubizwa mu mubiri.
Ibi bivuze ko ECM atari urwego rwo kurinda gusa; Mu by'ukuri, nk'uko byagaragajwe na Goodell na bagenzi be, mikorobe zisa n'aho zifite ubushobozi bwo kugenzura uburyo ECM yazo ifatana bityo bigatuma zibasha kwinjira. Babikora bate? Ifoto yatanzwe na: B. Goodell
Mu bihumyo, isohoka ry’ibihumyo rigaragara nk’aho ari aside oxalic, aside organic isanzwe iboneka mu bimera byinshi. Nk’uko Goodell na bagenzi be babibonye, ​​mikorobe nyinshi zisa nkaho zikoresha aside oxalic zisohora kugira ngo zifatanye n’urusobe rw’inyuma rwa karubohidrati, zigakora ECM ifatana, isa na gel.
Ariko ubwo itsinda ryarebaga neza, ryasanze aside oxalic itafashije gusa mu gukora ECM, ahubwo inayigenzura: uko aside oxalic nyinshi mikorobe zongerwa mu ruvange rwa aside karubohidrati, ni ko ECM irushaho kuba ndende. Uko ECM irushaho kuba ndende, ni ko irushaho gukumira molekile nini kwinjira cyangwa kuva muri mikorobe, mu gihe molekile nto ziguma zifunguye mu buryo bworoshye kwinjira muri mikorobe ziva mu bidukikije, ndetse n’izindi molekile.
Ubu buvumbuzi bubangamira imyumvire gakondo ya siyansi ku buryo ubwoko butandukanye bw'ibintu biva muri izi mikorobe na bagiteri biva muri izi mikorobe mu bidukikije. Goodell na bagenzi be bavuze ko mu bihe bimwe na bimwe mikorobe zishobora kwishingikiriza cyane ku isohoka ry'uturemangingo duto cyane kugira ngo zirwanye igice cyangwa ingingo iyo mikorobe yishingikirizaho kugira ngo ikomeze kubaho cyangwa iyandure.
Ibi bivuze ko gusohora utunyangingo duto bishobora no kugira uruhare runini mu gutera indwara iyo enzymes nini zidashobora kunyura muri matrix ya mikorobe iri hanze y’umubiri.
“Bigaragara ko hari ahantu hagati,” Goodell yagize ati, “aho mikorobe zishobora kugenzura urugero rw’aside kugira ngo zihuze n’ibidukikije runaka, zigagumana zimwe muri molekile nini, nka enzymes, mu gihe zituma molekile nto zinyura muri ECM byoroshye.”
Guhindura ECM hakoreshejwe aside oxalic bishobora kuba uburyo udukoko twirinda imiti irwanya udukoko na antibiyotike, kubera ko imiti myinshi igizwe na molekile nini cyane. Ubu bushobozi bwo guhindura ibintu ni bwo bushobora kuba ingenzi mu gutsinda imwe mu mbogamizi zikomeye mu kuvura antibiyotike, kuko gukoresha ECM kugira ngo irusheho kwinjira mu mubiri bishobora kunoza imikorere ya antibiyotike na antibiyotike.
Goodell yagize ati: “Niba dushobora kugenzura uburyo aside nto nka oxalate zikora ndetse n’uburyo zisohoka muri mikorobe zimwe na zimwe, dushobora no kugenzura ibijya muri mikorobe, ibyo bikaba byadufasha kuvura neza indwara nyinshi za mikorobe.”
Amakuru arambuye: Gabriel Perez-Gonzalez n'abandi, Imikoranire ya oxalates na beta-glucan: ingaruka ku matrix yo hanze y'ingirabuzimafatizo z'ibihumyo no gutwara metabolite, iScience (2023). DOI: 10.1016/j.isci.2023.106851
Niba uhuye n'ikosa ry'ikosa, amakosa, cyangwa wifuza gutanga icyifuzo cyo guhindura ibikubiye kuri uru rupapuro, nyamuneka koresha iyi fomu. Ku bibazo rusange, nyamuneka koresha fomu yacu yo kutwandikira. Kugira ngo ubone ibitekerezo rusange, koresha igice cy'ibitekerezo rusange kiri hepfo (kurikiza amabwiriza).
Ibitekerezo byanyu ni ingenzi cyane kuri twe. Ariko, kubera ubwinshi bw'ubutumwa, ntabwo dushobora kwemeza igisubizo cyihariye.
Aderesi imeri yawe ikoreshwa gusa mu kubwira abayoherereje imeri. Aderesi yawe cyangwa aderesi y'uwayohererejwe nta kindi kizakoreshwa. Amakuru wanditse azagaragara muri imeri yawe kandi ntazabikwa na Phys.org mu buryo ubwo aribwo bwose.
Akira amakuru mashya ya buri cyumweru cyangwa ya buri munsi mu gasanduku kawe k'ubutumwa. Ushobora kwiyambura igihe icyo ari cyo cyose kandi ntabwo tuzasangiza amakuru yawe abandi bantu.
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