Dukurikije amabwiriza akomeye y’ubuvanganzo mu guhitamo amasoko, duhuza gusa n’ibigo by’ubushakashatsi bya kaminuza, ibitangazamakuru byemewe, kandi aho bihari, ubushakashatsi bw’ubuvuzi busuzumwa n’urungano. Nyamuneka menya ko imibare iri mu dusanduku (1, 2, nibindi) ari amasano ashobora gukanda kuri ubu bushakashatsi.
Amakuru ari mu nyandiko zacu ntabwo agamije gusimbura uburyo bwo kuvugana n'umuganga w'inzobere mu by'ubuzima kandi ntabwo agamije gukoreshwa nk'inama z'abaganga.
Iyi nkuru ishingiye ku bimenyetso bya siyansi, byanditswe n'impuguke kandi bigasuzumwa n'itsinda ryacu ry'abanditsi bahuguwe. Menya ko imibare iri mu dusanduku (1, 2, nibindi) igaragaza aho ushobora gukanda ukande ugana ku bushakashatsi bw'ubuvuzi bwasuzumwe n'urungano.
Itsinda ryacu rigizwe n’abahanga mu mirire n’inzobere mu by’imirire, abarezi b’ubuzima bemewe, ndetse n’inzobere mu by’imbaraga n’imirire, abatoza ku giti cyabo n’inzobere mu myitozo ngororamubiri. Intego y’itsinda ryacu si ubushakashatsi bwimbitse gusa, ahubwo ni no kutabogama no kutabogama.
Amakuru ari mu nyandiko zacu ntabwo agamije gusimbura uburyo bwo kuvugana n'umuganga w'inzobere mu by'ubuzima kandi ntabwo agamije gukoreshwa nk'inama z'abaganga.
Imwe mu nyongeramusaruro zikoreshwa cyane mu miti n'inyongeramusaruro muri iki gihe ni magnesium stearate. Mu by'ukuri, bizakugora kubona inyongeramusaruro ku isoko uyu munsi idafite iyo nyongeramusaruro—haba tuvuga ku nyongeramusaruro za manyeziyumu, enzymes zituma umuntu arya, cyangwa indi nyongeramusaruro wihitiyemo—nubwo ushobora kutabona izina ryayo neza.
Akenshi yitwa andi mazina nka "stearate y'imboga" cyangwa ibikomoka kuri yo nka "aside stearic", iboneka hafi ya hose. Uretse kuba ikwirakwira hose, stearate ya manyeziyumu nayo ni kimwe mu bintu bikunze kuvugwaho rumwe mu rundi rwego rw'inyongeramusaruro.
Mu buryo bumwe, ibi bisa n'ibiganiro kuri Vitamine B17: ese ni uburozi cyangwa ni umuti wa kanseri? Ikibabaje ni uko rubanda, impuguke mu by'ubuzima karemano, abashakashatsi mu by'inyongeramusaruro, n'abaganga bakunze gutanga ibimenyetso bivuguruzanya kugira ngo bashyigikire ibitekerezo byabo bwite, kandi ukuri ku bintu biragoye cyane kubibona.
Ni byiza gufata ingamba zifatika zo kurwanya impaka nk'izo no kwirinda gufata uruhande rushingiye ku bitekerezo bikabije.
Ingingo y'ingenzi ni iyi: Kimwe n'ibindi bikoresho byinshi byo koza no gukurura, magnesium stearate ni mbi ku buzima iyo ikoreshejwe ku rugero rwo hejuru, ariko kuyinywa ntabwo ari bibi cyane nkuko bamwe babivuga kuko akenshi iboneka gusa ku rugero ruto cyane.
Magnesium stearate ni umunyu wa manyeziyumu wa aside stearic. Mu by'ukuri, ni ikintu kirimo ubwoko bubiri bwa aside stearic na manyeziyumu.
Aside ya Stearic ni aside yuzuye ibinure iboneka mu biribwa byinshi, harimo ibinure by’inyamaswa n’ibikomoka ku bimera n’amavuta. Kakao n’imbuto za flax ni ingero z’ibiribwa birimo aside nyinshi ya Stearic.
Nyuma yuko magnesium stearate igabanijwemo ibice bigize umubiri, ibinure byayo biba bisa cyane n'iby'aside stearic. Ifu ya magnesium stearate ikunze gukoreshwa nk'inyongera mu mirire, isoko y'ibiribwa ndetse n'inyongera mu kwisiga.
Magnesium stearate ni yo ikoreshwa cyane mu gukora ibinini kuko ari amavuta meza. Ikoreshwa kandi mu binini, ifu, n'ibiribwa byinshi, harimo bombo nyinshi, gummies, ibyatsi, ibirungo, n'ibikoresho byo guteka.
Izwi nka "umuti utuma ibintu bisohoka neza," ifasha kwihutisha igikorwa cyo gukora irinda ko ibikoresho bifatwa ku bikoresho bya mekanike. Ni uruvange rw'ifu rutwikira hafi imiti iyo ari yo yose cyangwa imvange y'inyongera hakoreshejwe urugero ruto gusa.
Ishobora kandi gukoreshwa nk'ikintu gitera imbaraga, gifata neza, gitera imbaraga, gikingira gufunga, amavuta yo kwisiga, ikintu gikuraho ibara n'ikintu gikuraho ibara.
Ntabwo ari ingirakamaro gusa mu gukora kuko bituma imashini zibikora zitwara neza, ahubwo inatuma ibinini byoroha kumira no kunyura mu nzira y'igifu. Magnesium stearate nayo ni ikintu gikunze gukoreshwa mu kongera ingaruka zo kuvura ibintu bitandukanye bikora mu miti kandi igatuma imiti ibasha kwinjiza no gushonga.
Bamwe bavuga ko bashobora gukora imiti cyangwa inyongeramusaruro zidafite ibintu bifasha mu kongera uburozi nka magnesium stearate, bigatuma bibaza impamvu ikoreshwa mu gihe hari ubundi buryo busanzwe. Ariko ibi bishobora kuba atari ko bimeze.
Hari ibicuruzwa byakozwe birimo ubundi buryo bwo gusimbura magnesium stearate hakoreshejwe ibintu bifasha mu kongera imbaraga nk'ibikomoka ku bimera nka ascorbyl palmitate, ariko ibi tubikorera aho bifite ishingiro atari uko twabitekereje nabi. Ariko, ubu buryo bwo gusimbura ntibugira ingaruka nziza buri gihe kuko bufite imiterere itandukanye.
Kugeza ubu ntibiramenyekana neza niba gusimbuza magnesium stearate bishoboka cyangwa se ari ngombwa.
Magnesium stearate ishobora kuba nziza iyo ikoreshejwe mu nyongeramusaruro ziboneka mu ntungamubiri n'ibiribwa. Mu by'ukuri, waba ubizi cyangwa utabizi, ushobora kuba wongeramo multivitamine, amavuta ya kokonati, amagi n'amafi buri munsi.
Kimwe n'izindi myunyu ngugu za chelated (magnesium ascorbate, magnesium citrate, nibindi), [nti]gira ingaruka mbi kuko igizwe n'imyunyu ngugu na aside de l'ibiryo (aside stearic y'imboga yakuweho umunyu wa manyeziyumu). Igizwe n'ibintu bitagira ingaruka mbi.
Ku rundi ruhande, Ikigo cy’Igihugu cy’Ubuzima (NIH) muri raporo yacyo ku birebana na magnesium stearate cyaburiye ko magnesium nyinshi ishobora kwangiza uburyo bwo kohereza imitsi mu bwonko no gutuma habaho intege nke no kugabanuka kw’imitekerereze. Nubwo ibi bidakunze kubaho cyane, Ikigo cy’Igihugu cy’Ubuzima (NIH) gitangaza ko:
Abantu ibihumbi n'ibihumbi bandura buri mwaka, ariko ibimenyetso bikomeye ntibikunze kugaragara. Uburozi bukomeye bukunze kubaho nyuma yo guterwa mu mitsi mu masaha menshi (akenshi muri preeclampsia) kandi bushobora kubaho nyuma yo gukoresha ibiyobyabwenge igihe kirekire, cyane cyane iyo impyiko zinaniwe gukora neza. Uburozi bukomeye bwagaragaye nyuma yo kunywa impyiko mu buryo butunguranye, ariko ni gake cyane.
Ariko, iyi raporo ntiyahumurije abantu bose. Gusuzuma gato kuri Google bizagaragaza ko magnesium stearate ifitanye isano n'ingaruka nyinshi, nka:
Kubera ko ikunda amazi (“ikunda amazi”), hari raporo zivuga ko magnesium stearate ishobora kugabanya umuvuduko wo gushonga kw'imiti n'inyongera mu nzira y'igifu. Imiterere yo kurinda magnesium stearate igira ingaruka ku bushobozi bw'umubiri bwo kwinjiza imiti n'intungamubiri, bigatuma umuti cyangwa inyongeramusaruro bitagira umumaro mu gihe umubiri udashobora kubigabanya neza.
Ku rundi ruhande, ubushakashatsi bwakozwe na Kaminuza ya Maryland buvuga ko magnesium stearate itagira ingaruka ku mubare w'ibinyabutabire biva muri propranolol hydrochloride, umuti ukoreshwa mu kugenzura gutera k'umutima no gutera imitsi mu bwonko, bityo akanama nkemurampaka karacyari hanze kugeza ubu.
Mu by’ukuri, abakora imiti bakoresha magnesium stearate kugira ngo bongere ubushobozi bwo gufata neza imiti no gutuma umuti winjira neza, bagatinda kwangirika kw’ibirimo kugeza igihe bigeze mu mara.
Uturemangingo twa T, igice cy'ingenzi cy'ubudahangarwa bw'umubiri cyibasira indwara ziterwa n'udukoko, ntitwibasirwa na magnesium stearate, ahubwo twibasirwa na aside stearic, igice cy'ingenzi kiri mu bintu bikunze gukoreshwa mu mubiri.
Byasobanuwe bwa mbere mu 1990 mu kinyamakuru Immunology, aho ubu bushakashatsi bw’ingenzi bwagaragaje uburyo ubudahangarwa bw’umubiri bushingiye kuri T bugabanuka iyo hari aside stearic yonyine.
Mu bushakashatsi bwakozwe n’Abayapani bwasuzumye ibintu bisanzwe bifasha mu gukurura, byagaragaye ko magnesium stearate y’imboga ari yo itera formaldehyde. Ariko, ibi bishobora kuba bidateye ubwoba nkuko bigaragara, kuko ibimenyetso bigaragaza ko formaldehyde iboneka mu mbuto nyinshi nshya, imboga n’ibikomoka ku matungo, harimo pome, imineke, epinari, kale, inyama z’inka ndetse no muri kawa.
Kugira ngo ugire icyo utekereza, magnesium stearate ikora formaldehyde nkeya kurusha izindi zose zapimwe: 0.3 nanogarama kuri garama ya magnesium stearate. Ugereranije, kurya ibihumyo byumye bya shiitake bitanga miligarama zirenga 406 za formaldehyde kuri kilo imwe uriye.
Mu 2011, Umuryango Mpuzamahanga wita ku Buzima wasohoye raporo ivuga uburyo amatsinda menshi ya magnesium stearate yandujwe n’ibinyabutabire bishobora kwangiza umubiri, birimo bisphenol A, calcium hydroxide, dibenzoylmethane, irganox 1010 na zeolite (sodium aluminum silicate).
Kubera ko iki ari ikintu cyihariye, ntidushobora gufata umwanzuro mbere y’igihe ko abantu bafata inyongeramusaruro n’imiti ibonekamo magnesium stearate bagomba kwitondera kwanduzanya uburozi.
Hari abantu bashobora kugira ibimenyetso by’ubwivumbure nyuma yo kunywa ibinyobwa cyangwa inyunganiramirire birimo magnesium stearate, bishobora gutera impiswi no kuribwa mu mara. Niba ufite ingaruka mbi ku nyongeramusaruro, ugomba gusoma neza ibyapa by’ibinyabutabire kandi ugakora ubushakashatsi gato kugira ngo ubone ibinyobwa bidakozwe mu nyongeramusaruro zizwi cyane.
Ikigo cy’Igihugu gishinzwe ikoranabuhanga mu by’ibinyabuzima gisaba ko dose ya 2500 mg ya magnesium stearate kuri kilo y’uburemere bw’umubiri ifatwa nk’ifite umutekano. Ku muntu mukuru upima ibiro bigera kuri 150, ibi bingana na miligarama 170.000 ku munsi.
Mu gihe utekereza ku ngaruka mbi zishobora guterwa na magnesium stearate, ni ingenzi gutekereza ku “gukoresha dose”. Mu yandi magambo, usibye gukoresha magnesium stearate mu mitsi ku ndwara zikomeye, ingaruka mbi za magnesium stearate zagaragaye gusa mu bushakashatsi bwa laboratwari aho imbeba zagaburirwaga ku ngufu kugeza ubwo nta muntu ku isi washoboraga kurya byinshi.
Mu 1980, ikinyamakuru Toxicology cyatangaje ibyavuye mu bushakashatsi aho imbeba 40 zagaburiwe indyo ikoze muri semi-synthetic irimo 0%, 5%, 10%, cyangwa 20% bya magnesium stearate mu gihe cy'amezi atatu. Dore ibyo yasanze:
Icyitonderwa ni uko ingano ya aside stearic na magnesium stearate ikunze gukoreshwa mu binini ari nto cyane. Aside stearic isanzwe ingana na 0.5–10% ukurikije uburemere bw'ikinini, mu gihe magnesium stearate isanzwe ingana na 0.25–1.5% ukurikije uburemere bw'ikinini. Bityo, ikinini cya 500 mg gishobora kuba kirimo hafi 25 mg ya aside stearic na hafi 5 mg ya magnesium stearate.
Ikintu cyose kirenze urugero gishobora kwangiza ubuzima bw'abantu kandi bashobora gupfa bazize kunywa amazi menshi, sibyo? Ibi ni ngombwa kubyibuka kuko kugira ngo magnesium stearate igirire umuntu nabi, aba akeneye gufata capsules/ibinini ibihumbi ku munsi.